Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.
نویسندگان
چکیده
منابع مشابه
Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.
Tumor necrosis factor (TNF) and interferon gamma (IFN-gamma) are pluripotent cytokines and have multiple functions during the inflammatory response. Using a murine model of autoimmune myocarditis, we studied the role of TNF and IFN-gamma in myocardial inflammation. Neutralizing monoclonal antibodies against TNF-alpha/beta and IFN-gamma were administered to myosin-immunized A/J mice to assess th...
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Tumor necrosis factor (TNF) and interferon gamma (IFN-'y) are pleuripotent cytokines and have multiple functions during the inflammatory response. Using a murine model of autoimmune myocarditis, we studied the role of TNF and IFN-y in myocardial inflammation. Neutralizing monoclonal antibodies against TNF-cx/f and IFN-ywere administered to myosin-immunized A/J mice to assess the effect on the s...
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15 صفحه اولExpression of tumor necrosis factor-alpha--converting enzyme and tumor necrosis factor-alpha in human myocarditis.
OBJECTIVES We determined whether tumor necrosis factor-alpha-converting enzyme (TACE) is expressed with tumor necrosis factor-alpha (TNF-alpha) in myocarditis. BACKGROUND Tumor necrosis factor-alpha-converting enzyme, which has recently been identified as belonging to the family of metalloproteinase disintegrin proteins, is responsible for the conversion of TNF-alpha precursor to its mature f...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1992
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.70.4.856